In collaboration with OHB-System AG, Bremen, OWIS has designed and developed the “Air Flow Shutter” for the Air Flow System (AFS) of the European Physiology Laboratory Module (EPM) for the use in the Columbus Laboratory (COL) on board the International Space Station (ISS). The air-flow control element regulates the air flow produced by a central blower providing the necessary air cooling capability for the lab. Using this technology, up to eight different on-board experiments are possible at the same time. Beside the special technology, the challenge was the ultra high precision and quality in order to ensure absolutely reliable operation of the eight air-flow shutters.